Guys, I can't seem to get globalAlignment to use any scoring scheme otehr than seqan::Simple: TAlign align; seqan::resize(rows(align), 2); assignSource(row(align,0),seqA); assignSource(row(align,1),seqB); int score = globalAlignment(align, seqan::Score<int,seqan::Simple>(0,-1,-1,gapOpenPenalty)); I tried changing the last line to just: int score = globalAlignment(align, seqan::Score<int,Pam>(0,-1,-1,gapOpenPenalty)); and every conceivable variant thereof. None seem to be recognized, e.g.: /Users/Sam/svn/RNAToolbox/trunk/src/ParameterReader.cpp:1000:65: error: use of undeclared identifier 'Pam' Can someone tell me how to switch to Blossum, PAM, or some other? Thanks Sam